I organize my scene collections as chunks of areas like a grid so I know what needs to be disabled when the camera doesn't have it in view.

Scenes can be massive in size and the contents as well and instead of going through the scene collection list, I'd rather press one button for a whole area than select files in an entire list.

GPU Isolate mode should be used on Scene Collections when users toggle the Visibility State.

It might be helpful to add a record button above Collections column so that when the scene is playing, you can click on a scene collection to isolate and it gets recorded to the timeline. Once the recording is on, the scene could be observed through the mini viewport set to view with a low poly render to keep track of when to switch Scene Collection Isolation.