In iClone4 you can create various faces with puppeteering feature.
Select a character.
Toggle to Animation/Facial Animation.
Go to the Facial Edit section and click the Puppet button in the Modify Panel.
Click the Detail button to launch the Model Detail window.
Select the blue points to move each Facial Muscle region.
Selected Point
Result
If you have selected multiple points, you can move all the points all at once.
Click the Eraser button to clear all the selected red points.
Check Mirror to enable symmetry for both side of the face.
Click the Reset button to restore last modification.
Click the Reset All button to restore all the changes to the original face.